Antoaneta Sawyer, PhD
Most scientists believe that metabolic syndrome is conglomeration of three or four diseases that together can portend a worse prognosis for certain illnesses, including number of cancers. What has not been well-defined until that moment— is the associated risk for colorectal cancer.
A national survey report presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology scientific meeting in Orlando, Florida (October, 6) concluded that patients coping with the metabolic syndrome have a 75% higher risk for developing colorectal cancer sometime in their lives (Garrow & Delegge, 2008). (Source, NH-WC"Beyond Holistic")
The authors’ purpose was to review and analyze data collected between 2000 and 2003 by the National Health Interview Survey (NHIS). Their survey was centralized on 1,200 survey participants with history of metabolic syndrome and 350 patients with a family history of colorectal cancer.
Cross-referencing disease data revealed that patients with metabolic syndrome do bear higher risk for colorectal cancer as the study showed a 75% increase. According to their opinion, this is one of the first—and certainly the largest—study to look specifically at colorectal cancer risk.
The National Survey Report read at the American College of Gastroenterology scientific meeting in Orlando, Florida concluded that there is indeed a higher (75%) risk for colorectal cancer in this population.
Similar results on the connection of metabolic syndrome, obesity and diabetes and cancer were gathered in studies of colon cancer (Cowey & Hardy, 2006) breast cancer (Goodwin et al., 2005), pancreatic cancer (Huxley et al., 2005), prostate cancer( (Hammarsten & Hogstedt, 2004), and endometrial cancer (Cust et al., 2007, T. Bjorge et al., 2010; and Lane, 2008).
In Cowey and Hardy's words, " Specifically, we examine the hypothesis that individual components of the metabolic syndrome contribute to the development of several processes, including insulin resistance, aromatase activity, adipokine production, angiogenesis, glucose utilization, and oxidative stress/DNA damage, which can work together to increase cancer risk beyond that of the individual components alone. We propose that the metabolic syndrome be considered as a high-risk state for certain types of cancer and that this relationship should be systematically explored across cancer types."
Metabolic syndrome and obesity are also associated with an increased risk for clear-cell renal carcinoma (RCC), according to results reported in the January issue of BJU International (2010; 105, 16-20). The goal of this study was to evaluate the association between body mass index (BMI) and histology of RCC in a cohort of 1640 patients with renal cortical tumors being surgically removed from January, 2000 to December, 2007. Of these tumors, 12% were benign and 88% were malignant, while 61% of the last ones were clear-cell RCCs.
The lead author William T. Lawrence, from Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, stated, "This makes it more important than ever to identify those people who face an increased risk of developing this variant, which is on the rise in the USA." The association of BMI with RCC histological features was examined with multivariable logistic regression by the researchers. The lead researcher concluded, "The widespread use of abdominal imaging has definitely contributed to increased detection of RCC, but fails to account for it entirely." A number of studies have suggested that obesity could be a risk factor for RCC, but the exact reason is still unknown. Researchers speculated that it might be secondary to hormonal changes, decreased immune function, hypertension or diabetes in obese patients.
Obesity, defined as a BMI of equal or more than 30 kg/m2, was found in 38% of patients. BMI was associated with clear-cell renal carcinoma (RCC) histological features, after adjustment for tumor size, age, sex, American Society of Anesthesiologists (ASA) score, estimated glomerular filtration rate (GFR), hypertension, diabetes mellitus, and smoking. (Source, Wiki)
BMI was considered an independent predictor of clear-cell renal carcinoma histology in the subgroup of patients with RCC “We also looked at other health and lifestyle factors, like diabetes, hypertension and smoking. This showed that the only other factors that were independent predictors of clear-cell RCC were male gender and tumor size" concluded the author.
Finally the authors stated, "This study is useful as it provides individual predictors of the chance of developing this form of RCC cancer and obesity provides the strongest association." (Source, NH-WC "Beyond Holistic")
A national survey report presented at the 73rd Annual Scientific Meeting of the American College of Gastroenterology scientific meeting in Orlando, Florida (October, 6) concluded that patients coping with the metabolic syndrome have a 75% higher risk for developing colorectal cancer sometime in their lives (Garrow & Delegge, 2008). (Source, NH-WC"Beyond Holistic")
The authors’ purpose was to review and analyze data collected between 2000 and 2003 by the National Health Interview Survey (NHIS). Their survey was centralized on 1,200 survey participants with history of metabolic syndrome and 350 patients with a family history of colorectal cancer.
Cross-referencing disease data revealed that patients with metabolic syndrome do bear higher risk for colorectal cancer as the study showed a 75% increase. According to their opinion, this is one of the first—and certainly the largest—study to look specifically at colorectal cancer risk.
The National Survey Report read at the American College of Gastroenterology scientific meeting in Orlando, Florida concluded that there is indeed a higher (75%) risk for colorectal cancer in this population.
Similar results on the connection of metabolic syndrome, obesity and diabetes and cancer were gathered in studies of colon cancer (Cowey & Hardy, 2006) breast cancer (Goodwin et al., 2005), pancreatic cancer (Huxley et al., 2005), prostate cancer( (Hammarsten & Hogstedt, 2004), and endometrial cancer (Cust et al., 2007, T. Bjorge et al., 2010; and Lane, 2008).
In Cowey and Hardy's words, " Specifically, we examine the hypothesis that individual components of the metabolic syndrome contribute to the development of several processes, including insulin resistance, aromatase activity, adipokine production, angiogenesis, glucose utilization, and oxidative stress/DNA damage, which can work together to increase cancer risk beyond that of the individual components alone. We propose that the metabolic syndrome be considered as a high-risk state for certain types of cancer and that this relationship should be systematically explored across cancer types."
Metabolic syndrome and obesity are also associated with an increased risk for clear-cell renal carcinoma (RCC), according to results reported in the January issue of BJU International (2010; 105, 16-20). The goal of this study was to evaluate the association between body mass index (BMI) and histology of RCC in a cohort of 1640 patients with renal cortical tumors being surgically removed from January, 2000 to December, 2007. Of these tumors, 12% were benign and 88% were malignant, while 61% of the last ones were clear-cell RCCs.
The lead author William T. Lawrence, from Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, stated, "This makes it more important than ever to identify those people who face an increased risk of developing this variant, which is on the rise in the USA." The association of BMI with RCC histological features was examined with multivariable logistic regression by the researchers. The lead researcher concluded, "The widespread use of abdominal imaging has definitely contributed to increased detection of RCC, but fails to account for it entirely." A number of studies have suggested that obesity could be a risk factor for RCC, but the exact reason is still unknown. Researchers speculated that it might be secondary to hormonal changes, decreased immune function, hypertension or diabetes in obese patients.
Obesity, defined as a BMI of equal or more than 30 kg/m2, was found in 38% of patients. BMI was associated with clear-cell renal carcinoma (RCC) histological features, after adjustment for tumor size, age, sex, American Society of Anesthesiologists (ASA) score, estimated glomerular filtration rate (GFR), hypertension, diabetes mellitus, and smoking. (Source, Wiki)
BMI was considered an independent predictor of clear-cell renal carcinoma histology in the subgroup of patients with RCC “We also looked at other health and lifestyle factors, like diabetes, hypertension and smoking. This showed that the only other factors that were independent predictors of clear-cell RCC were male gender and tumor size" concluded the author.
Finally the authors stated, "This study is useful as it provides individual predictors of the chance of developing this form of RCC cancer and obesity provides the strongest association." (Source, NH-WC "Beyond Holistic")
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