Antoaneta Sawyer, Ph.D.
Human Growth Hormone (HGH) is a hormone produced by the anterior pituitary gland in the brain. It facilitates the building of bone and muscle as well as the production of cells that help organs and tissues grow and repair themselves. It also provides for the growth and repair of human muscles and tissue in advanced aging and has also show rejuvenating, regenerating effects on the human body that have been documented in multiple of scientific papers. I call HGH-the old age Performance Enhancer. Humans begin producing HGH at birth and varying levels of HGH circulate in the bloodstream until death. HGH levels reach their peak during adolescence and begin to drop with each passing year. Many scientists link this decrease to multiple health threatening degenerative diseases and complications of the aging process which include loss of muscle(sarcopenia) and bone strength, increase in body fat and decrease in immune function along with other common problems. In addition to the above, HGH promotes metabolism and the way the body uses energy.
As we age, (beginning as early as age 25), our HGH levels decline to a fraction of the levels of our age. Many in anti-aging medicine believe that supplementing our diets with HGH is an effective way to avoid the diseases and conditions associated with aging and improve vitality and appearance. Human Growth Hormone promotes tissue repair, cell regeneration in the bones, muscles and vital organs, and supports the immune system in combating infection and disease. There are multiple symptoms and factors of aging that negatively affect quality of life, such as increased body fat, loss of lean muscle tissue, lower energy levels, decreased sexual function, common depressive symptoms, and weakened immune function or decreased skin turgor (Gause-Nilsson et al., 2006; Scuteri, Najjar, Morrell & Lakatta, 2005). An increasing prevalence of the metabolic syndrome among U.S. adults is proved in a study of Ford et al. (2004).
The “neuroendocrine theory of aging” and its connection with multiple degenerative diseases is researched by Dean (1960). The metabolic pattern of aging is explained as a combination of: (a) reduced receptor sensitivity to insulin (insulin resistance); (b) obesity; c) altered lipid profile (elevated VLDL, LDL, triglycerides, and total cholesterol; (d) hypercortisolemia (elevated cortisol and decreased DHEA); (e) decreased androgen output in men; (f) increased gonadotropins (LH and FSH); (g) decreased immunity and increased incidence of autoimmune antibodies; (h) elevated blood pressure and (i) functional hypothyroidism. The entire aging cascade causes hormonal and metabolic shifts that can lead to aging, degenerative diseases and future mortality. Although it may seem strange, abdominal fat could affect the human brain, and be responsible for dementia in advanced age (Earl et al., 2002).
Rudman’s HGH theory (1985), postulates that HGH requires: (a). Pituitary/ hypothalamus stimulation; (b). Pancreatic regulation for optimum production of insulin and blood sugar in the blood, glucagon, leptin and cortisol levels, and (c). Correct hepatic (liver) nourishment and functioning for the conversion of HGH to insulin growth factor 1 (IGF-1). The author considers the following requirements for a proper HGH production: (a). Strong Protein metabolism as in general, growth hormone stimulates protein anabolism in many tissues. This effect reflects on the increased amino acid uptake, increased protein synthesis and decreased oxidation of proteins; (b). Active Fat metabolism: Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes, and (c). Healthy Carbohydrate metabolism: Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range.
As explained in the HERS (2002) study, the low circulating level of hormones (HGH and testosterone in particular) promotes an increase in adipose tissue bulk. This leads to free fatty acids release, which are immediately transported to the liver, consequently stimulating the production of Apo-B, containing very low density lipoproteins (VLDL). Insulin resistance leads to overproduction of triglyceride-rich lipoproteins and there is also a reduced activity of peripheral lipoprotein lipase which in turn supports the accumulation of triglyceride-rich lipoproteins in the circulation. Hlatky et al. (2002) teach that via the action of cholesterol ester transfer protein, triglycerides are transferred from these lipoproteins to high density lipoproteins in exchange for cholesterol esters. The enrichment of the triglyceride-rich remnant particles with cholesterol ester leads to formation of small dense LDL, known as VLDL. Moreover, because of this exchange, the level of high density lipoprotein (HDL) cholesterol falls (p.595).
Giampapa et al. (2004) consider usual that in aging people the body ability to metabolize glucose is progressively diminishing. The authors agreethat the aging body cannot respond to the action of insulin, resulting in elevated levels of glucose in the bloodstream, referred to as "glucose intolerance” and this is what causes aged people to become overweight, due to continual “wear and tear” of the pancreas from years of eating with a final decrease in the overall amount of insulin and other important hormone production (p.56). According to the authors, HGH is the most important hormone that stimulates the process of fat burning. Thus, chronic elevation in blood sugar not only creates insulin resistance, obesity, Type 2 diabetes and cardiovascular disease, but can also decrease the secretion of HGH (the main hormone of youth) leading to premature aging.
Another study done Papadakis et al. (1996) proves that complementary human growth hormone replacement can improve body composition in healthy older men, without changes in functional ability. As conclusion from the research, HGH production is proved to be a complex process that requires normal function of other organs and hormones to work. HGH effect in metabolic syndrome healing can be easily explained with its effects on protein, lipid and carbohydrate metabolism.
A validated age report correlated with HGH in centenarian prevalence is seen also in another study (Perls, Bohen, Freeman, Alpert & Silver, 1999). In some cases a direct effect of growth hormone has been clearly demonstrated, in others IGF-I it has been thought to be the critical mediator, and in some cases it appeared that both (direct and indirect) effects are at play (Perls et al., 1999; Papadakis et al., 1996). HGH is often said to have an “anti-insulin” activity, because it simply suppresses the abilities of insulin to stimulate the re-uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver (Giampapa et al., 2004). Somewhat paradoxically, administration of growth hormone may stimulate insulin secretion, leading to hyperinsulinemia (Papadakis et al., 1996).
According to the New England Journal of Medicine published studies (1990) HGH helps:* Restoring muscle mass* Decreasing body fat* Deeper Sleep* Thickening the skin, reducing wrinkles* Restoring lost hair* Restoring hair color* Increasing energy* Improving cholesterol profile* Restoring the size of internal organs (liver, pancreas and heart)* Improving vision* Improving memory* Elevating mood and improving sleep* Increasing cardiac output and stamina* Improving immune function* Increasing mental function* Increasing sex drive
The effect of HGH in metabolic syndrome healing can be easily explained with its important effects on protein, lipid and carbohydrate metabolism. In some cases, a direct effect of growth hormone has been clearly demonstrated, in others, IGF-I has been thought to be the critical mediator, and in some cases it appears that both (direct and indirect) effects are at play:
· Protein metabolism: In general, growth hormone stimulates protein anabolism in many tissues. This effect reflects increased amino acid uptake, increased protein synthesis and decreased oxidation of proteins.
· Fat metabolism: Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes.
· Carbohydrate metabolism: Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range. HGH is often said to have anti-insulin activity, because it suppresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver. Somewhat paradoxically, administration of growth hormone stimulates insulin secretion, leading to hyperinsulinemia.
Human Growth Hormone (HGH) is a hormone produced by the anterior pituitary gland in the brain. It facilitates the building of bone and muscle as well as the production of cells that help organs and tissues grow and repair themselves. It also provides for the growth and repair of human muscles and tissue in advanced aging and has also show rejuvenating, regenerating effects on the human body that have been documented in multiple of scientific papers. I call HGH-the old age Performance Enhancer. Humans begin producing HGH at birth and varying levels of HGH circulate in the bloodstream until death. HGH levels reach their peak during adolescence and begin to drop with each passing year. Many scientists link this decrease to multiple health threatening degenerative diseases and complications of the aging process which include loss of muscle(sarcopenia) and bone strength, increase in body fat and decrease in immune function along with other common problems. In addition to the above, HGH promotes metabolism and the way the body uses energy.
As we age, (beginning as early as age 25), our HGH levels decline to a fraction of the levels of our age. Many in anti-aging medicine believe that supplementing our diets with HGH is an effective way to avoid the diseases and conditions associated with aging and improve vitality and appearance. Human Growth Hormone promotes tissue repair, cell regeneration in the bones, muscles and vital organs, and supports the immune system in combating infection and disease. There are multiple symptoms and factors of aging that negatively affect quality of life, such as increased body fat, loss of lean muscle tissue, lower energy levels, decreased sexual function, common depressive symptoms, and weakened immune function or decreased skin turgor (Gause-Nilsson et al., 2006; Scuteri, Najjar, Morrell & Lakatta, 2005). An increasing prevalence of the metabolic syndrome among U.S. adults is proved in a study of Ford et al. (2004).
The “neuroendocrine theory of aging” and its connection with multiple degenerative diseases is researched by Dean (1960). The metabolic pattern of aging is explained as a combination of: (a) reduced receptor sensitivity to insulin (insulin resistance); (b) obesity; c) altered lipid profile (elevated VLDL, LDL, triglycerides, and total cholesterol; (d) hypercortisolemia (elevated cortisol and decreased DHEA); (e) decreased androgen output in men; (f) increased gonadotropins (LH and FSH); (g) decreased immunity and increased incidence of autoimmune antibodies; (h) elevated blood pressure and (i) functional hypothyroidism. The entire aging cascade causes hormonal and metabolic shifts that can lead to aging, degenerative diseases and future mortality. Although it may seem strange, abdominal fat could affect the human brain, and be responsible for dementia in advanced age (Earl et al., 2002).
Rudman’s HGH theory (1985), postulates that HGH requires: (a). Pituitary/ hypothalamus stimulation; (b). Pancreatic regulation for optimum production of insulin and blood sugar in the blood, glucagon, leptin and cortisol levels, and (c). Correct hepatic (liver) nourishment and functioning for the conversion of HGH to insulin growth factor 1 (IGF-1). The author considers the following requirements for a proper HGH production: (a). Strong Protein metabolism as in general, growth hormone stimulates protein anabolism in many tissues. This effect reflects on the increased amino acid uptake, increased protein synthesis and decreased oxidation of proteins; (b). Active Fat metabolism: Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes, and (c). Healthy Carbohydrate metabolism: Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range.
As explained in the HERS (2002) study, the low circulating level of hormones (HGH and testosterone in particular) promotes an increase in adipose tissue bulk. This leads to free fatty acids release, which are immediately transported to the liver, consequently stimulating the production of Apo-B, containing very low density lipoproteins (VLDL). Insulin resistance leads to overproduction of triglyceride-rich lipoproteins and there is also a reduced activity of peripheral lipoprotein lipase which in turn supports the accumulation of triglyceride-rich lipoproteins in the circulation. Hlatky et al. (2002) teach that via the action of cholesterol ester transfer protein, triglycerides are transferred from these lipoproteins to high density lipoproteins in exchange for cholesterol esters. The enrichment of the triglyceride-rich remnant particles with cholesterol ester leads to formation of small dense LDL, known as VLDL. Moreover, because of this exchange, the level of high density lipoprotein (HDL) cholesterol falls (p.595).
Giampapa et al. (2004) consider usual that in aging people the body ability to metabolize glucose is progressively diminishing. The authors agreethat the aging body cannot respond to the action of insulin, resulting in elevated levels of glucose in the bloodstream, referred to as "glucose intolerance” and this is what causes aged people to become overweight, due to continual “wear and tear” of the pancreas from years of eating with a final decrease in the overall amount of insulin and other important hormone production (p.56). According to the authors, HGH is the most important hormone that stimulates the process of fat burning. Thus, chronic elevation in blood sugar not only creates insulin resistance, obesity, Type 2 diabetes and cardiovascular disease, but can also decrease the secretion of HGH (the main hormone of youth) leading to premature aging.
Another study done Papadakis et al. (1996) proves that complementary human growth hormone replacement can improve body composition in healthy older men, without changes in functional ability. As conclusion from the research, HGH production is proved to be a complex process that requires normal function of other organs and hormones to work. HGH effect in metabolic syndrome healing can be easily explained with its effects on protein, lipid and carbohydrate metabolism.
A validated age report correlated with HGH in centenarian prevalence is seen also in another study (Perls, Bohen, Freeman, Alpert & Silver, 1999). In some cases a direct effect of growth hormone has been clearly demonstrated, in others IGF-I it has been thought to be the critical mediator, and in some cases it appeared that both (direct and indirect) effects are at play (Perls et al., 1999; Papadakis et al., 1996). HGH is often said to have an “anti-insulin” activity, because it simply suppresses the abilities of insulin to stimulate the re-uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver (Giampapa et al., 2004). Somewhat paradoxically, administration of growth hormone may stimulate insulin secretion, leading to hyperinsulinemia (Papadakis et al., 1996).
According to the New England Journal of Medicine published studies (1990) HGH helps:* Restoring muscle mass* Decreasing body fat* Deeper Sleep* Thickening the skin, reducing wrinkles* Restoring lost hair* Restoring hair color* Increasing energy* Improving cholesterol profile* Restoring the size of internal organs (liver, pancreas and heart)* Improving vision* Improving memory* Elevating mood and improving sleep* Increasing cardiac output and stamina* Improving immune function* Increasing mental function* Increasing sex drive
The effect of HGH in metabolic syndrome healing can be easily explained with its important effects on protein, lipid and carbohydrate metabolism. In some cases, a direct effect of growth hormone has been clearly demonstrated, in others, IGF-I has been thought to be the critical mediator, and in some cases it appears that both (direct and indirect) effects are at play:
· Protein metabolism: In general, growth hormone stimulates protein anabolism in many tissues. This effect reflects increased amino acid uptake, increased protein synthesis and decreased oxidation of proteins.
· Fat metabolism: Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes.
· Carbohydrate metabolism: Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range. HGH is often said to have anti-insulin activity, because it suppresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver. Somewhat paradoxically, administration of growth hormone stimulates insulin secretion, leading to hyperinsulinemia.
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These statements have not been evaluated by the Food and Drug Administration. The material in this newsletter is provided for informational purposes only. Thus our intentions are not to diagnose, cure, mitigate, treat or prevent any disease. If you use the information in this newsletter without the approval of your health professional, the authors of this letter do not assume any responsibility. Copyright @ 2009, Natural Health-Wellness LLC. All rights reserved.
These statements have not been evaluated by the Food and Drug Administration. The material in this newsletter is provided for informational purposes only. Thus our intentions are not to diagnose, cure, mitigate, treat or prevent any disease. If you use the information in this newsletter without the approval of your health professional, the authors of this letter do not assume any responsibility. Copyright @ 2009, Natural Health-Wellness LLC. All rights reserved.
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